Detalhe da pesquisa
1.
High-Dose Isoniazid Lacks EARLY Bactericidal Activity Against Isoniazid-resistant Tuberculosis Mediated by katG Mutations: A Randomized, Phase 2 Clinical Trial.
Am J Respir Crit Care Med
; 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38564365
2.
Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis.
Antimicrob Agents Chemother
; 68(4): e0156223, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38376228
3.
Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosis.
Antimicrob Agents Chemother
; 67(12): e0078923, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37966090
4.
Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model.
Antimicrob Agents Chemother
; 67(4): e0003523, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36920217
5.
Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy.
Antimicrob Agents Chemother
; 67(7): e0048123, 2023 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37338374
6.
Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial.
Am J Respir Crit Care Med
; 205(10): 1228-1235, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35258443
7.
Potential Impact of Long-Acting Products on the Control of Tuberculosis: Preclinical Advancements and Translational Tools in Preventive Treatment.
Clin Infect Dis
; 75(Suppl 4): S510-S516, 2022 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36410384
8.
CRISPR Inhibition of Essential Peptidoglycan Biosynthesis Genes in Mycobacterium abscessus and Its Impact on ß-Lactam Susceptibility.
Antimicrob Agents Chemother
; 66(4): e0009322, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35311518
9.
T405, a New Penem, Exhibits In Vivo Efficacy against M. abscessus and Synergy with ß-Lactams Imipenem and Cefditoren.
Antimicrob Agents Chemother
; 66(6): e0053622, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35638855
10.
Novel Regimens of Bedaquiline-Pyrazinamide Combined with Moxifloxacin, Rifabutin, Delamanid and/or OPC-167832 in Murine Tuberculosis Models.
Antimicrob Agents Chemother
; 66(4): e0239821, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35315690
11.
Combination of Mycobacterium tuberculosis RS Ratio and CFU Improves the Ability of Murine Efficacy Experiments to Distinguish between Drug Treatments.
Antimicrob Agents Chemother
; 66(4): e0231021, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35311519
12.
GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.
Antimicrob Agents Chemother
; 66(6): e0013222, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35607978
13.
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering.
PLoS Pathog
; 16(2): e1008287, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32032366
14.
A Semimechanistic Model of the Bactericidal Activity of High-Dose Isoniazid against Multidrug-Resistant Tuberculosis: Results from a Randomized Clinical Trial.
Am J Respir Crit Care Med
; 204(11): 1327-1335, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34403326
15.
Pharmacodynamic Correlates of Linezolid Activity and Toxicity in Murine Models of Tuberculosis.
J Infect Dis
; 223(11): 1855-1864, 2021 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31993638
16.
In Vitro Activity of Bedaquiline and Imipenem against Actively Growing, Nutrient-Starved, and Intracellular Mycobacterium abscessus.
Antimicrob Agents Chemother
; 65(12): e0154521, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516254
17.
Comparative Efficacy of the Novel Diarylquinoline TBAJ-876 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis.
Antimicrob Agents Chemother
; 65(12): e0141221, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34570644
18.
Impact of Dose, Duration, and Immune Status on Efficacy of Ultrashort Telacebec Regimens in Mouse Models of Buruli Ulcer.
Antimicrob Agents Chemother
; 65(11): e0141821, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34460302
19.
Comparative Efficacy of the Novel Diarylquinoline TBAJ-587 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis.
Antimicrob Agents Chemother
; 65(4)2021 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33526488
20.
Early Bactericidal Activity of Different Isoniazid Doses for Drug-Resistant Tuberculosis (INHindsight): A Randomized, Open-Label Clinical Trial.
Am J Respir Crit Care Med
; 201(11): 1416-1424, 2020 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31945300